Volunteers with Type 2 Diabetes needed for an exercise metabolism research study

Are you a man or woman with Type II Diabetes aged 20-45 and interested in being involved in a research project? We are looking for volunteers to participate in a metabolism study investigating how fat stored in your muscle affects insulin activity.

Exclusions: You cannot participate if you: smoke, have hyperlipidemia, or have been told by your doctor not to exercise. You must be diagnosed <10 years ago, and be treated for diabetes using diet and exercise, and/or sulfonylureas, and/or acarbose only.

Women volunteers should NOT BE using oral contraceptives.

Two different preliminary assessments will measure:

Ø Body fat content

Ø Maximal exercise capacity (VO 2max)

Ø Heart rhythm

Ø Resting metabolic rate

Ø Glucose tolerance

Ø Blood tests

Ø Health and physical examination performed by a physician.

Volunteers will complete one metabolic study day following a 12 hour fast, where you will lie quietly for 4 hours, exercise for 1.5 hours at an easy to moderate intensity (45% of maximal capacity), and lie quietly again after exercise for 2 hours. All 3 visits will be performed at the General Clinical Research Center. Diet will be controlled for 3 days before each study day.

For the metabolic study day, the following will occur:

Ø Infusion of naturally occurring tracer of carbohydrate and fat through an intravenous catheter

Ø Blood sampling from a catheter placed in a hand vein

Ø 3 muscle biopsies

Ø 1.5 hours of exercise at 45% of maximal capacity

Compensation will be provided.

Please call Mary at 303-724-3968 or email mary.playdon@uchsc.edu for more information about this study.